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patients with ulcerative colitis** Ulcerative colitis, a form of inflammatory bowel disease , is a condition in which the lining of the large intestine  and rectum become inflamed** Co says the study showed significant improvements over placebo in clinical recovery, symptom relief, and showed reduction in signs of disease severity within 12 weeks** Co says the study achieved a response rate of 63.5% vs 27% for placebo** PTGX had risen 24.2% in the past 12 months, as of last close  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& Johnson Gets Health Canada Approval for Lung Cancer Drug Combination","url":"https://stock-news.laohu8.com/highlight/detail?id=2518662229","media":"MT Newswires Live","labels":["productRelease"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2518662229?lang=en_us&edition=fundamental","pubTime":"2025-03-10 20:58","pubTimestamp":1741611490,"startTime":"0","endTime":"0","summary":"Johnson & Johnson  said Monday that Health Canada authorized lazcluze in combination with rybrevant as a first-line treatment for certain patients with advanced non-small cell lung cancer.The company said the approval is based on a phase 3 study of the combination in patients with locally advanced or metastatic non-small cell lung cancer with epidermal growth factor receptor exon 19 deletions or exon 21 L858R substitution mutations.The trial showed that the combination reduced the risk of disease progression or death by 30% compared with osimertinib, with a median progression-free survival of 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The median duration of response was 25.8 months, nine months longer than with osimertinib, the company said.The drugmaker said its Janssen unit holds marketing authorization for lazcluze and rybrevant in 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trea...","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/johnson-johnson-health-canada-authorizes-lazcluze-rybrevant-combo?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/johnson-johnson-health-canada-authorizes-lazcluze-rybrevant-combo?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"policyRegulatory","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["LU1732800096.USD","IE00B3PB1722.GBP","IE0002270589.USD","IE00BSNM7G36.USD","LU1061106388.HKD","LU1066051498.USD","LU0640476718.USD","LU1066053197.SGD","LU1066051811.HKD","LU1929549753.HKD","IE00BDGV0183.EUR","LU2347655156.SGD","LU2592432038.USD","LU0345769128.USD","LU2129689431.USD","LU0320765646.SGD","LU1162221912.USD","LU0203347892.USD","LU1244550494.USD","LU2468319806.SGD","SG9999002224.SGD","BK4568","IE000M9KFDE8.USD","LU0889566641.SGD","LU1032466523.USD","LU1196500208.SGD","LU0345770308.USD","LU0234572021.USD","LU1244550577.SGD","BK4532","IE00B42XCP33.USD","IE00BJJMRZ35.SGD","LU1894683348.USD","IE0002141913.USD","LU0203345920.USD","LU0466842654.USD","LU0122379950.USD","LU2112291526.USD","LU1732799900.SGD","LU2089984988.USD","LU1059921491.USD","LU0912757837.SGD","BK4007","JNJ","BK4592","LU2505996509.AUD","IE00BVYPNV92.GBP","IE00B19Z3B42.SGD","IE00BGHQF631.EUR","BK4504"],"gpt_icon":0},{"id":"2518225421","title":"Johnson & Johnson's Investigational Colitis Treatment Meets Primary Endpoint in Phase 2b Trial","url":"https://stock-news.laohu8.com/highlight/detail?id=2518225421","media":"MT Newswires Live","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2518225421?lang=en_us&edition=fundamental","pubTime":"2025-03-10 20:35","pubTimestamp":1741610122,"startTime":"0","endTime":"0","summary":"Johnson & Johnson  said Monday that its potential ulcerative colitis treatment icotrokinra met the primary endpoint of clinical response in all dosages in a 252-patient phase 2b study.The investigational drug also showed \"clinically meaningful\" differences versus placebo in secondary endpoints of clinical remission, symptomatic remission, and endoscopic improvement at week 12, the company said.Icotrokinra at the highest doses showed a response rate of 63.5% for patients with chronic large intestine disease after 12 weeks, versus 27% for placebo, and a remission rate of 30.2%, versus 11.1% for the placebo, the company said.It added that remission and response rates continued to improve through week 28.","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["LU2129689431.USD","LU0203345920.USD","IE00B4R5TH58.HKD","LU1066051811.HKD","LU1732800096.USD","LU1244550494.USD","LU0114720955.EUR","LU1032955483.USD","LU2089984988.USD","IE00BJT1NW94.SGD","LU1674673691.USD","IE00BSNM7G36.USD","LU0466842654.USD","JNJ","LU0234572021.USD","LU1059921491.USD","LU1074936037.SGD","IE00BDGV0183.EUR","LU0345769631.USD","LU1162221912.USD","LU1066053197.SGD","IE00B42XCP33.USD","LU1929549753.HKD","LU2505996681.GBP","BK4581","LU2129689605.HKD","BK4592","IE00B2B36J28.USD","SG9999001440.SGD","LU0882574055.USD","LU2133065610.SGD","LU1061106388.HKD","LU0345770993.USD","LU0203347892.USD","IE00B19Z3581.USD","LU2347655156.SGD","LU0058720904.USD","LU2468319806.SGD","LU0795875169.SGD","LU2602419157.SGD","LU0289739699.SGD","BK4533","BK4585","LU0098860793.USD","BK4559","LU1066051225.USD","BK4007","LU1894683264.USD","LU1914381329.SGD","SG9999002224.SGD"],"gpt_icon":0},{"id":"2518256772","title":"Health Canada Authorizes Lazcluze® (Lazertinib) in Combination With Rybrevant® (Amivantamab) as a First-Line Chemotherapy-Free Treatment for Patients With Egfr-Mutated Advanced Lung Cancer","url":"https://stock-news.laohu8.com/highlight/detail?id=2518256772","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2518256772?lang=en_us&edition=fundamental","pubTime":"2025-03-10 20:30","pubTimestamp":1741609808,"startTime":"0","endTime":"0","summary":null,"market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250310:nFWN3PT0MP:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["LU1280957306.USD","LU1261432733.SGD","LU1032955483.USD","BK4550","LU0795875086.SGD","LU2112291526.USD","LU1066051225.USD","LU1196500208.SGD","LU1894683348.USD","LU0466842654.USD","LU1074936037.SGD","IE00B19Z3B42.SGD","LU2430703251.USD","IE0002141913.USD","LU1066051811.HKD","LU2347655156.SGD","LU1221951129.SGD","LU2129689605.HKD","LU0289739699.SGD","IE00BJJMRZ35.SGD","LU0058720904.USD","BK4581","LU0203347892.USD","LU2089984988.USD","LU0889566641.SGD","LU0203345920.USD","IE00BDGV0183.EUR","LU0234572021.USD","SG9999001440.SGD","IE00B1BXHZ80.USD","LU1032466523.USD","LU0320765646.SGD","LU2430703095.HKD","LU0114720955.EUR","LU1778281490.HKD","LU0882574055.USD","SG9999002224.SGD","IE00B2B36J28.USD","LU1732800096.USD","LU2602419157.SGD","LU0234570918.USD","LU2505996681.GBP","BK4585","LU2133065610.SGD","LU0345769631.USD","BK4559","LU1894683264.USD","JNJ","IE00BGHQF631.EUR","BK4592"],"gpt_icon":0},{"id":"2518226306","title":"Health Canada authorizes LAZCLUZE® (lazertinib) in combination with RYBREVANT® (amivantamab) as a first-line chemotherapy-free treatment for patients with EGFR-mutated advanced lung cancer","url":"https://stock-news.laohu8.com/highlight/detail?id=2518226306","media":"CNW Group","labels":["productRelease"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2518226306?lang=en_us&edition=fundamental","pubTime":"2025-03-10 20:30","pubTimestamp":1741609800,"startTime":"0","endTime":"0","summary":"Phase 3 MARIPOSA study showedLAZCLUZE plus RYBREVANT significantly improved progression-free survival, reducing the risk of disease progression or death by 30 per cent versus osimertinib alone.1. TORONTO, March 10, 2025 /CNW/ - Johnson & Johnson  announced today that Health Canada has issued a Notice of Compliance  for LAZCLUZE  in combination with RYBREVANT  for the first-line treatment of adult patients with locally advanced or metastatic non-small cell lung cancer  with epidermal growth factor receptor  exon 19 deletions or exon 21 L858R substitution mutations.1 Janssen Inc., a Johnson & Johnson company, is the market authorization holder for LAZCLUZE  and RYBREVANT in Canada.\"Each breakthrough in the treatment of lung cancer provides new hope for patients,\" says Shem Singh***, Executive Director of Lung Cancer Canada. \"Findings from the MARIPOSA study show new progress in the treatment of NSCLC with EGFR mutations, including a meaningful increase in progression-free survival. The a","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/health-canada-authorizes-lazcluze-lazertinib-123000098.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"productRelease","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["LU0203345920.USD","LU1032466523.USD","LU0640476718.USD","LU1032955483.USD","BK4564","IE00BJJMRZ35.SGD","LU0122379950.USD","BK4187","JNJ","IE00B3PB1722.GBP","LU0345770308.USD","LU1261432733.SGD","SG9999002224.SGD","LU1988902786.USD","LU1066051225.USD","IE00B4R5TH58.HKD","LU1674673691.USD","IE00B2B36J28.USD","LU2129689431.USD","LU0792757196.USD","LU1221951129.SGD","LU1066051811.HKD","BK4585","LU1061106388.HKD","LU0345770993.USD","BK4534","BK4504","IE00B42XCP33.USD","LU1244550577.SGD","LU1778281490.HKD","LU2129689514.USD","NOC","LU0289739699.SGD","LU2264538146.SGD","LU0234570918.USD","LU2133065610.SGD","LU2430703095.HKD","IE0009355771.USD","LU1506573853.SGD","SG9999002232.USD","BK4603","IE00BDGV0183.EUR","IE00B7SZLL34.SGD","LU0912757837.SGD","PFS","LU1914381329.SGD","LU1066053197.SGD","LU1585245621.USD","BK4533","IE0002270589.USD"],"gpt_icon":0},{"id":"2518226539","title":"Protagonist Reports Positive Top Line Results From Phase 2b Study of Icotrokinra Showing Potential to Transform the Treatment Paradigm for Patients With Ulcerative Colitis","url":"https://stock-news.laohu8.com/highlight/detail?id=2518226539","media":"ACCESS Newswire","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2518226539?lang=en_us&edition=fundamental","pubTime":"2025-03-10 20:15","pubTimestamp":1741608900,"startTime":"0","endTime":"0","summary":"Clinical response rate of 63.5% and clinical remission rate of 30.2% achieved at Week 12 with the highest dose, which continued to improve through Week 28. All three doses met the primary endpoint of clinical response at Week 12, with a favorable safety profile. These results in ulcerative colitis build on strong data recently reported for the plaque psoriasis Phase 3 program. NEWARK, CALIFORNIA / ACCESS Newswire / March 10, 2025 / Protagonist Therapeutics, Inc.  today announced positive topline results from ANTHEM-UC, a Phase 2b study of icotrokinra , the first investigational targeted oral peptide that selectively blocks the IL-23 receptor, in adults with moderately to severely active ulcerative colitis . The study conducted by Protagonist's collaboration partner, Johnson & Johnson, met its primary endpoint of clinical responsea in all icotrokinra dose groups evaluated. Additionally, the study demonstrated clinically meaningful differences versus placebo in key secondary endpoints 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Meets Primary Endpoint of Clinical Response in Ulcerative Colitis Study and Shows Potential to Transform the Treatment Paradigm for Patients","url":"https://stock-news.laohu8.com/highlight/detail?id=2518228165","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2518228165?lang=en_us&edition=fundamental","pubTime":"2025-03-10 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Icotrokinra Was Well Tolerated","url":"https://stock-news.laohu8.com/highlight/detail?id=2518228141","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2518228141?lang=en_us&edition=fundamental","pubTime":"2025-03-10 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meets primary endpoint of clinical response in ulcerative colitis study and shows potential to transform the treatment paradigm for patients","url":"https://stock-news.laohu8.com/highlight/detail?id=2518223792","media":"PR Newswire","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2518223792?lang=en_us&edition=fundamental","pubTime":"2025-03-10 20:00","pubTimestamp":1741608000,"startTime":"0","endTime":"0","summary":"Clinical response and remission rates continued to improve through Week 28, building on strong data recently reported for the plaque psoriasis Phase 3 program. Icotrokinra demonstrates potential to offer therapeutic benefit and tolerability with a once daily oral treatment. SPRING HOUSE, Pa., March 10, 2025 /PRNewswire/ -- Johnson & Johnson today announced positive topline results from ANTHEM-UC, a Phase 2b study of icotrokinra , the first investigational targeted oral peptide that selectively blocks the IL-23 receptor, in adults with moderately to severely active ulcerative colitis . The study met its primary endpoint of clinical responsea in all icotrokinra dose groups evaluated and demonstrated clinically meaningful differences versus placebo in key secondary endpoints of clinical remissionb, symptomatic remission and endoscopic improvement at Week 12.","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"yahoofinance","url":"https://finance.yahoo.com/news/icotrokinra-meets-primary-endpoint-clinical-120000377.html","rn_cache_url":null,"customStyle":"img, svg { display: none !important; }","selectors":"article","filters":"","directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/icotrokinra-meets-primary-endpoint-clinical-120000377.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["LU2468319806.SGD","IE00BVYPNW00.USD","IE00B19Z3B42.SGD","IE00B7SZLL34.SGD","LU1280957306.USD","LU2430703251.USD","IE00B4R5TH58.HKD","LU1221951046.USD","LU0289739699.SGD","LU1032466523.USD","BK4559","LU0345770308.USD","LU0640476718.USD","LU1674673691.USD","LU1718418525.SGD","IE00BJJMRZ35.SGD","LU0792757196.USD","LU1162221912.USD","LU2505996681.GBP","LU1061106388.HKD","LU1244550494.USD","LU0098860793.USD","LU1914381329.SGD","LU1935042991.SGD","LU0320765646.SGD","LU0345770993.USD","LU2430703178.SGD","LU1674673428.USD","LU1778281490.HKD","LU2430703095.HKD","BK4532","LU1506573853.SGD","IE0034235303.USD","IE000M9KFDE8.USD","JNJ","LU0122379950.USD","LU1196500208.SGD","BK4568","LU1244550577.SGD","LU0345769631.USD","LU2133065610.SGD","IE0002141913.USD","IE0009355771.USD","BK4504","LU1261432733.SGD","LU2347655156.SGD","LU1221951129.SGD","LU0203345920.USD","BK4534","LU1430594728.SGD"],"gpt_icon":0},{"id":"2518322144","title":"Take the Zacks Approach to Beat the Markets: NioCorp, AngloGold, Amgen in Focus","url":"https://stock-news.laohu8.com/highlight/detail?id=2518322144","media":"Zacks","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2518322144?lang=en_us&edition=fundamental","pubTime":"2025-03-10 18:35","pubTimestamp":1741602900,"startTime":"0","endTime":"0","summary":"The three most widely followed U.S. indexes ended in red last week. The S&P 500, the Dow Jones Industrial Average and the Nasdaq Composite slid 1.36%, 0.90% and 0.84%, respectively. The aggressive shifting of U.S. policies and foreign trade tariffs with major trading partnersunder President DonaldTrump’s new administration has compelled investors to rethink their strategies. Concerns also surfaced over a slowdown in economic growth and rise in inflation due to the new government policies.Personal consumption expenditure , the Fed’s preferred inflation gauge, increased by 0.3% in January, higher than the Federal Reserve’s 2% target, and showed a 2.5% annual rate. The disproportion between the rise in personal income by 0.9% and the unexpected decline in personal spending by 0.2% in January indicates that average Americans are concerned about future economic conditions. Retail sales and building construction decreased last month. 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Johnson & Johnson JNJ.N:J&J - ICOTROKINRA RESULTS SHOW POTENTIAL TO SET A NEW STANDARD OF TREATMENT ","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250308:nFWN3PR08D:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["LU1162221912.USD","BK4592","IE00B3PB1722.GBP","LU2347655156.SGD","LU1935042991.SGD","BK4007","LU0234572021.USD","LU1221951046.USD","LU2430703178.SGD","LU2468319806.SGD","BK4559","SG9999002232.USD","LU2129689431.USD","LU0889566641.SGD","LU0122379950.USD","IE00B7SZLL34.SGD","IE00BFTCPJ56.SGD","JNJ","LU1267930813.SGD","IE00B1BXHZ80.USD","IE00BDGV0183.EUR","IE00B2B36J28.USD","LU2089984988.USD","LU2505996681.GBP","LU1057294990.SGD","LU2505996509.AUD","IE00BSNM7G36.USD","IE00B19Z3B42.SGD","LU0466842654.USD","BK4585","LU0345769128.USD","LU1032955483.USD","LU2133065610.SGD","LU0320765646.SGD","BK4504","SG9999002224.SGD","LU0058720904.USD","LU1585245621.USD","LU1196500208.SGD","IE0034235303.USD","LU2129689605.HKD","LU0098860793.USD","IE0002141913.USD","IE00B42XCP33.USD","LU1061106388.HKD","LU1066051498.USD","LU1894683264.USD","LU1718418525.SGD","SG9999001440.SGD","LU2112291526.USD"],"gpt_icon":0},{"id":"2517444168","title":"J&J - 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Nearly half of patients with moderate-to-severe plaque psoriasis  treated with investigational icotrokinra achieved completely clear skin  at Week 24 in Phase 3 ICONIC-LEAD. Topline results from Phase 3 ICONIC-ADVANCE 1&2studies show icotrokinra achieved co-primary endpoints and showed superiority to deucravacitinib in moderate-to-severe plaque PsO. Data from the Phase 3 ICONIC-LEADa study, presented as a late-breaking abstract at the 2025 American Academy of Dermatology  Annual Meeting, show once daily icotrokinra demonstrated significant skin clearance and a favorable safety profile in adults and adolescents 12 years of age and older with moderate-to-severe plaque PsO.1. \"People living with moderate-to-severe plaque psoriasis are seeking options that balance efficacy, safety and ease of use,\" said Robert Bissonnette, M.D., Chairman at Innovaderm Research, ","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"yahoofinance","url":"https://finance.yahoo.com/news/icotrokinra-results-show-potential-set-140000829.html","rn_cache_url":null,"customStyle":"img, svg { display: none !important; }","selectors":"article","filters":"","directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/icotrokinra-results-show-potential-set-140000829.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["IE00BSNM7G36.USD","LU1732799900.SGD","LU1221951046.USD","LU0203347892.USD","LU1244550577.SGD","BK4568","IE000M9KFDE8.USD","LU0114720955.EUR","LU1894683348.USD","LU2112291526.USD","JNJ","BK4585","IE00BDGV0183.EUR","LU1162221912.USD","LU1074936037.SGD","LU1778281490.HKD","LU0345770993.USD","IE0002270589.USD","RCT","LU0122379950.USD","LU0882574055.USD","LU0345769631.USD","IGA","LU2468319806.SGD","LU1585245621.USD","LU0889566641.SGD","BK4581","BK4534","BK4588","LU1506573853.SGD","BK4559","BK4550","LU0203345920.USD","LU1261432733.SGD","IE00B19Z3581.USD","LU0912757837.SGD","LU1066051225.USD","LU0234570918.USD","LU1280957306.USD","LU2602419157.SGD","LU0795875169.SGD","LU1023059063.AUD","LU2089984988.USD","IE00B19Z3B42.SGD","IE00B1BXHZ80.USD","LU1066051811.HKD","SG9999001440.SGD","BK4533","LU0640476718.USD"],"gpt_icon":0}],"pageSize":16,"totalPage":13,"pageCount":1,"totalSize":200}]}}