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After Hours","url":"https://stock-news.laohu8.com/highlight/detail?id=2501951932","media":"MT Newswires Live","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2501951932?lang=en_us&edition=fundamental","pubTime":"2025-01-07 06:30","pubTimestamp":1736202628,"startTime":"0","endTime":"0","summary":"Denali Therapeutics  said Monday the phase 2/3 Healey-ALS platform trial of eIF2B activator DNL343 as a treatment for amyotrophic lateral sclerosis missed primary and secondary endpoints.\"The study did not meet the primary endpoint of efficacy in slowing disease progression as compared with placebo,\" the company said in a statement. \"Key secondary endpoints, measuring muscle strength and respiratory function, were also not statistically different between the active and placebo groups at week 24.\"\"DNL343 was found to be safe and well tolerated,\" the company said.The company said further evaluation will be conducted later this year, including neurofilament light and other fluid biomarkers, data from prespecified subgroups, as well as extended findings from the active treatment extension period.Shares of the company fell 5.7% in after-hours activity.Price: 18.70, Change: -1.12, Percent Change: -5.65","market":"hk","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-2","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["BK4535","LENZ","BK4548","BK4139","DNLI"],"gpt_icon":0},{"id":"2501293634","title":"Denali Therapeutics Says ALS Trial Didn't Meet Endpoints","url":"https://stock-news.laohu8.com/highlight/detail?id=2501293634","media":"Dow Jones","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2501293634?lang=en_us&edition=fundamental","pubTime":"2025-01-07 06:07","pubTimestamp":1736201220,"startTime":"0","endTime":"0","summary":"Denali Therapeutics said the latest trial of its treatment for amyotrophic lateral sclerosis, or ALS, didn't meet its primary or secondary endpoints after 24 weeks.The biotechnology company said Monday that DNL343 didn't meet the primary endpoint of slowing disease progression as compared with a placebo. Secondary endpoints measuring muscle strength and respiratory function weren't statistically different between active and placebo groups.The treatment was found to be safe and well tolerated, and further analyses are anticipated later this year.\"Though the initial top-line clinical results of this trial were not what we hoped, the data collected is valuable in helping to understand the next stage of ALS research,\" said Merit Cudkowicz, the principal investigator of the trial.Shares fell 7.7% to $18.30 in after-market trading.","market":"sh","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4139","BK4535","LENZ","DNLI","BK4548"],"gpt_icon":0},{"id":"2501298047","title":"UPDATE 1-Denali Therapeutics' ALS drug fails in mid-to-late stage trial","url":"https://stock-news.laohu8.com/highlight/detail?id=2501298047","media":"Reuters","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2501298047?lang=en_us&edition=fundamental","pubTime":"2025-01-07 05:59","pubTimestamp":1736200774,"startTime":"0","endTime":"0","summary":"(Adds details on study and next steps in paragraphs 2-4)      Jan 6 (Reuters) - Denali Therapeutics    said on Monday its experimental drug failed to meet the main goal of a mid-to-late stage trial in","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.rkd.refinitiv.com/api/News/News.svc/REST/News_1/RetrieveStoryML_1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-2","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4139","LENZ","BK4548","DNLI","BK4535"],"gpt_icon":0},{"id":"2501298420","title":"Denali Therapeutics announces HEALEY ALS trial regimen misses endpoints","url":"https://stock-news.laohu8.com/highlight/detail?id=2501298420","media":"TIPRANKS","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2501298420?lang=en_us&edition=fundamental","pubTime":"2025-01-07 05:40","pubTimestamp":1736199657,"startTime":"0","endTime":"0","summary":"Denali Therapeutics (DNLI) announced topline results from an analysis of Regimen G of the Phase 2/3 HEALEY ALS Platform Trial evaluating eIF2B agon...","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/denali-therapeutics-announces-healey-als-trial-regimen-misses-endpoints?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/denali-therapeutics-announces-healey-als-trial-regimen-misses-endpoints?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["DNLI","LENZ","BK4139","BK4548","BK4535"],"gpt_icon":0},{"id":"2501260048","title":"Denali Therapeutics ALS drug fails in mid-stage trial","url":"https://stock-news.laohu8.com/highlight/detail?id=2501260048","media":"Reuters","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2501260048?lang=en_us&edition=fundamental","pubTime":"2025-01-07 05:38","pubTimestamp":1736199483,"startTime":"0","endTime":"0","summary":"Denali Therapeutics ALS drug fails in mid-stage trialJan 6  - Denali Therapeutics DNLI.O said on Monday its experimental drug failed to meet the main goal of a mid-to-late stage trial in patients with amyotrophic lateral sclerosis , a fatal neurodegenerative disease.  ","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250106:nL4N3O21EJ:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-2","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4535","BK4548","DNLI","BK4139"],"gpt_icon":0},{"id":"2501260667","title":"Denali Therapeutics Inc - Study Did Not Meet Primary Endpoint of Slowing Disease Progression","url":"https://stock-news.laohu8.com/highlight/detail?id=2501260667","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2501260667?lang=en_us&edition=fundamental","pubTime":"2025-01-07 05:30","pubTimestamp":1736199007,"startTime":"0","endTime":"0","summary":null,"market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250106:nTUA1QKMCR:2","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["BK4139","DNLI","BK4548","BK4535"],"gpt_icon":0}],"pageSize":16,"totalPage":6,"pageCount":4,"totalSize":93}]}}