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Phase 2/3 Healey ALS Platform Trial","url":"https://stock-news.laohu8.com/highlight/detail?id=2501260650","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2501260650?lang=en_us&edition=fundamental","pubTime":"2025-01-07 05:30","pubTimestamp":1736199007,"startTime":"0","endTime":"0","summary":null,"market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250106:nTUA1QKMCR:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["BK4535","DNLI","BK4139","BK4548"],"gpt_icon":0},{"id":"2501260108","title":"Denali Therapeutics Announces Topline Results for Regimen G Evaluating eIF2B Agonist DNL343 in the Phase 2/3 HEALEY ALS Platform Trial","url":"https://stock-news.laohu8.com/highlight/detail?id=2501260108","media":"GlobeNewswire","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2501260108?lang=en_us&edition=fundamental","pubTime":"2025-01-07 05:30","pubTimestamp":1736199000,"startTime":"0","endTime":"0","summary":"Primary endpoint of overall function (ALSFRS-R) and survival, and key secondary endpoints of muscle strength and respiratory function, were not met at 24 weeksOverall, DNL343 was found to be safe and ","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.globenewswire.com/news-release/2025/01/06/3005002/0/en/Denali-Therapeutics-Announces-Topline-Results-for-Regimen-G-Evaluating-eIF2B-Agonist-DNL343-in-the-Phase-2-3-HEALEY-ALS-Platform-Trial.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["LENZ","BK4548","BK4139","DNLI","BK4535"],"gpt_icon":0},{"id":"2500033125","title":"Denali Therapeutics Neurodegenerative Disease Platform Sparks Analyst Optimistic","url":"https://stock-news.laohu8.com/highlight/detail?id=2500033125","media":"Benzinga","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2500033125?lang=en_us&edition=fundamental","pubTime":"2025-01-04 02:08","pubTimestamp":1735927682,"startTime":"0","endTime":"0","summary":"William Blair has initiated coverage on Denali Therapeutics Inc , a company focused on developing drugs for neurodegenerative diseases.The analyst highlights that Denali is developing a specialized transport vehicle  platform to enhance the delivery of treatments across the blood-brain barrier.It stands out from competitors with its promising potential for top-tier performance and scalability across different therapies and conditions.The company’s lead program Tividenofusp alfa, an enzyme-replacement therapy for Hunter syndrome, shows promise as a best-in-class treatment, the analyst highlights.The company has reached an agreement with the FDA on the requirements for accelerated approval and plans to submit a biologics license application in early 2025.Insights gained from tividenofusp alfa may also simplify the development and approval process for future treatments targeting other lysosomal storage diseases, such as DNL126 for Sanfilippo syndrome type A.Most recently, Denali 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Therapeutics Initiated at Outperform by William Blair","url":"https://stock-news.laohu8.com/highlight/detail?id=2500119234","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2500119234?lang=en_us&edition=fundamental","pubTime":"2025-01-03 22:15","pubTimestamp":1735913700,"startTime":"0","endTime":"0","summary":"Ratings actions from Benzinga: https://www.benzinga.com/quote/DNLI/analyst-ratings \n\n\n \n\n\n  (END) Dow Jones Newswires\n\n\n  January 03, 2025 09:15 ET (14:15 GMT)","market":"hk","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["DNLI","LENZ"],"gpt_icon":0},{"id":"2492958755","title":"Denali Therapeutics upgraded to Buy from Hold at Stifel","url":"https://stock-news.laohu8.com/highlight/detail?id=2492958755","media":"TipRanks","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2492958755?lang=en_us&edition=fundamental","pubTime":"2024-12-17 19:25","pubTimestamp":1734434742,"startTime":"0","endTime":"0","summary":"Discover top-rated stocks from highly ranked analysts with Analyst Top Stocks!Easily identify outperforming stocks and invest smarter with Top Smart Score Stocks. Denali Therapeutics announces first patient dosed in Phase 2a study of BIIB122. Denali Therapeutics management to meet with B. Riley. Denali Therapeutics sees Fy24 opex increase of 5%-10% year-over-year","market":"us","thumbnail":"https://s.yimg.com/uu/api/res/1.2/mZDcjNmmKhClNQkla1p5GA--~B/aD0xOTI7dz0xOTI7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/tipranks_452/d622151edd421d0d1465b02718e80caa","type":0,"news_type":0,"thumbnails":["https://s.yimg.com/uu/api/res/1.2/mZDcjNmmKhClNQkla1p5GA--~B/aD0xOTI7dz0xOTI7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/tipranks_452/d622151edd421d0d1465b02718e80caa"],"rights":{"source":"yahoofinance","url":"https://finance.yahoo.com/news/denali-therapeutics-upgraded-buy-hold-112542267.html","rn_cache_url":null,"customStyle":"img, svg { display: none !important; }","selectors":"article","filters":"","directOrigin":true},"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/denali-therapeutics-upgraded-buy-hold-112542267.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["DNLI","SF","LENZ"],"gpt_icon":0},{"id":"2491660496","title":"Stifel Nicolaus Upgrades Denali Therapeutics to Buy From Hold, Raises Price Target to $37 From $28","url":"https://stock-news.laohu8.com/highlight/detail?id=2491660496","media":"MT Newswires Live","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2491660496?lang=en_us&edition=fundamental","pubTime":"2024-12-16 20:32","pubTimestamp":1734352376,"startTime":"0","endTime":"0","summary":"Denali Therapeutics (DNLI) has an average rating of Buy and mean price target of $42.77, according to analysts polled by FactSet.(MT Newswires covers equity, commodity and economic research from major","market":"sg","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["LENZ","DNLI","SF"],"gpt_icon":0},{"id":"2490708284","title":"We're Hopeful That Denali Therapeutics (NASDAQ:DNLI) Will Use Its Cash Wisely","url":"https://stock-news.laohu8.com/highlight/detail?id=2490708284","media":"Simply Wall St.","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2490708284?lang=en_us&edition=fundamental","pubTime":"2024-12-09 19:19","pubTimestamp":1733743141,"startTime":"0","endTime":"0","summary":"There's no doubt that money can be made by owning shares of unprofitable businesses. For example, biotech and mining...","market":"sg","thumbnail":"https://images.simplywall.st/asset/industry/6111000-choice1-main-header/1585186710114","type":0,"news_type":0,"thumbnails":["https://images.simplywall.st/asset/industry/6111000-choice1-main-header/1585186710114"],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://simplywall.st/stocks/us/pharmaceuticals-biotech/nasdaq-dnli/denali-therapeutics/news/were-hopeful-that-denali-therapeutics-nasdaqdnli-will-use-it","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"simplywall_highlight","symbols":["NDAQ","PSQ","DNLI","BK4112","SQQQ","QID","BK4588","BK4535","QLD","IE00B64PRP62.GBP","TQQQ","IE00BGHQF748.EUR","NQmain","BK4548","BK4585",".IXIC","IE00B3QW5Z07.USD","LU2210149790.SGD","LU2210150020.SGD","MNQmain","LU2095319765.USD","IE00BKPKM429.USD","BK4139"],"gpt_icon":1},{"id":"2489725163","title":"Why Is Denali Therapeutics (DNLI) Down 21.2% Since Last Earnings Report?","url":"https://stock-news.laohu8.com/highlight/detail?id=2489725163","media":"Zacks","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2489725163?lang=en_us&edition=fundamental","pubTime":"2024-12-07 00:31","pubTimestamp":1733502676,"startTime":"0","endTime":"0","summary":"A month has gone by since the last earnings report for Denali Therapeutics Inc. . Shares have lost about 21.2% in that time frame, underperforming the S&P 500.Will the recent negative trend continue leading up to its next earnings release, or is Denali Therapeutics due for a breakout?Before we dive into how investors and analysts have reacted as of late, let's take a quick look at its most recent earnings report in order to get a better handle on the important drivers.Denali Q3 Earnings Miss Estimates, Pipeline Progress Encouraging. Denali incurred a third-quarter 2024 loss of 63 cents per share, wider than the Zacks Consensus Estimate of a loss of 60 cents. The company reported a loss of 72 cents in the year-ago quarter.The bottom line improved year over year despite a rise in operating expenses, mainly due to an increase in the number of shares outstanding.In the absence of a marketed product, the company only recognizes revenues from ongoing collaborations. Denali did not generate c","market":"us","thumbnail":"https://s.yimg.com/uu/api/res/1.2/HIalcDlt7JZPKSITVlxPuw--~B/aD02MDA7dz05MDA7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/c2fdcaac033e049c74f38d188afcc9f9","type":0,"news_type":0,"thumbnails":["https://s.yimg.com/uu/api/res/1.2/HIalcDlt7JZPKSITVlxPuw--~B/aD02MDA7dz05MDA7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/c2fdcaac033e049c74f38d188afcc9f9"],"rights":null,"property":["earning"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/why-denali-therapeutics-dnli-down-163116909.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["SNY","AGIO","DNLI"],"gpt_icon":0},{"id":"2489237703","title":"Denali Starts Dosing in Phase II Parkinson's Disease Study","url":"https://stock-news.laohu8.com/highlight/detail?id=2489237703","media":"Zacks","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2489237703?lang=en_us&edition=fundamental","pubTime":"2024-12-06 22:48","pubTimestamp":1733496480,"startTime":"0","endTime":"0","summary":"Denali Therapeutics Inc. DNLI initiated dosing in a global mid-stage study, BEACON, on BIIB122 .BIIB122, an investigational drug leucine-rich repeat kinase 2  inhibitor, is being evaluated in participants with LRRK2-associated Parkinson’s disease .Shares of DNLI have risen 8.7% year to date against the industry’s 8.4% decline.The phase IIa study will evaluate safety and biomarkers associated with oral daily dosing of BIIB122 in approximately 50 participants with Parkinson’s disease and LRRK2 pathogenic mutations confirmed by genetic testing.In September, Denali announced that its meeting with the FDA's Center for Drug Evaluation and Research  division to advance DNL310 was successful.The meeting with CDER outlined a path for Denali to file a biologics license application  seeking accelerated approval of tividenofusp alfa  for the treatment of MPS II and its subsequent conversion to full approval.Denali agreed with the CDER that cerebrospinal fluid heparan sulfate  is reasonably likely ","market":"us","thumbnail":"https://s.yimg.com/uu/api/res/1.2/.UMP6LIbiG0Pb3tKR9RYYw--~B/aD00MDA7dz02MzU7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/1566882a22938942efee3e7508e93e96","type":0,"news_type":0,"thumbnails":["https://s.yimg.com/uu/api/res/1.2/.UMP6LIbiG0Pb3tKR9RYYw--~B/aD00MDA7dz02MzU7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/1566882a22938942efee3e7508e93e96"],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/denali-starts-dosing-phase-ii-144800152.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["IE00B894F039.SGD","BK4585","IE00B19Z9Z06.USD","BK4533","BK4532","IE00B19Z9P08.USD","LU0234570918.USD","LU0109394709.USD","BK4007","DNLI","IE00BFXG1179.USD","SPRO","SNY","LU0889565916.HKD","LU0320765992.SGD","BIIB","BK4548","BK4139","ETV","BK4588","BK4535"],"gpt_icon":0},{"id":"2489456016","title":"Denali Therapeutics announces first patient dosed in Phase 2a study of BIIB122","url":"https://stock-news.laohu8.com/highlight/detail?id=2489456016","media":"TIPRANKS","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2489456016?lang=en_us&edition=fundamental","pubTime":"2024-12-05 21:10","pubTimestamp":1733404259,"startTime":"0","endTime":"0","summary":"Denali Therapeutics (DNLI) announced initiation of dosing in a global Phase 2a clinical study, BEACON, of the investigational drug leucine-rich rep...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/denali-therapeutics-announces-first-patient-dosed-in-phase-2a-study-of-biib122?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/denali-therapeutics-announces-first-patient-dosed-in-phase-2a-study-of-biib122?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["BK4535","BK4139","LENZ","DNLI","BK4548"],"gpt_icon":0},{"id":"2489455296","title":"Denali Therapeutics Announces First Participant Dosed in Phase 2a Study of  Lrrk2 Inhibitor, Biib122, in Lrrk2-Associated Parkinson’s Disease","url":"https://stock-news.laohu8.com/highlight/detail?id=2489455296","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2489455296?lang=en_us&edition=fundamental","pubTime":"2024-12-05 21:00","pubTimestamp":1733403603,"startTime":"0","endTime":"0","summary":null,"market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20241205:nTUA9RL2TZ:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["BK4548","BK4139","DNLI","BK4535"],"gpt_icon":0},{"id":"2482821764","title":"Denali Q3 Earnings Miss Estimates, Pipeline Progress Encouraging","url":"https://stock-news.laohu8.com/highlight/detail?id=2482821764","media":"Zacks","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2482821764?lang=en_us&edition=fundamental","pubTime":"2024-11-08 23:08","pubTimestamp":1731078480,"startTime":"0","endTime":"0","summary":"Shares of Denali Therapeutics DNLI rose marginally yesterday after the company reported third-quarter results on Wednesday.Denali incurred a third-quarter 2024 loss of 63 cents per share, wider than the Zacks Consensus Estimate of a loss of 60 cents. The company reported a loss of 72 cents in the year-ago quarter.The bottom line improved year over year despite a rise in operating expenses, mainly due to an increase in the number of shares outstanding.In the absence of a marketed product, the company only recognizes revenues from ongoing collaborations. Denali did not generate collaboration revenues in the reported quarter. The Zacks Consensus Estimate for revenues was pegged at $21 million. In the year-ago quarter, the company recorded collaboration revenues of $1.3 million.Shares of DNLI have risen 37.9% year to date against the industry’s 2.4% decline.DNL343, an eIF2B activator, is being evaluated in a phase II/III HEALEY study to treat ALS. Enrollment has been completed in Regimen G","market":"us","thumbnail":"https://s.yimg.com/uu/api/res/1.2/.WQmSb1MJO1_eLnmBVS1zA--~B/aD00MDA7dz02MzU7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/a1d7049b0977a02a21fd2aa02b46f307","type":0,"news_type":0,"thumbnails":["https://s.yimg.com/uu/api/res/1.2/.WQmSb1MJO1_eLnmBVS1zA--~B/aD00MDA7dz02MzU7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/a1d7049b0977a02a21fd2aa02b46f307"],"rights":null,"property":["earning"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/denali-q3-earnings-miss-estimates-150800178.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["DNLI","PRGS","SNY"],"gpt_icon":0},{"id":"2481869671","title":"Denali Therapeutics (DNLI) Receives a Hold from Stifel Nicolaus","url":"https://stock-news.laohu8.com/highlight/detail?id=2481869671","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2481869671?lang=en_us&edition=fundamental","pubTime":"2024-11-07 22:39","pubTimestamp":1730990381,"startTime":"0","endTime":"0","summary":"Stifel Nicolaus analyst Paul Matteis maintained a Hold rating on Denali Therapeutics (DNLI – Research Report) today and set a price target of $28.0...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/blurbs/denali-therapeutics-dnli-receives-a-hold-from-stifel-nicolaus?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/blurbs/denali-therapeutics-dnli-receives-a-hold-from-stifel-nicolaus?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["BK4535","SF","DNLI","BK4548","BK4139","BK4127"],"gpt_icon":0},{"id":"2481907350","title":"Denali Therapeutics Inc : Wedbush Raises Target Price to $33 From $30","url":"https://stock-news.laohu8.com/highlight/detail?id=2481907350","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2481907350?lang=en_us&edition=fundamental","pubTime":"2024-11-07 21:32","pubTimestamp":1730986363,"startTime":"0","endTime":"0","summary":null,"market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20241107:nFWN3ME1PV:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["DNLI","BK4548","BK4535","BK4139"],"gpt_icon":0}],"pageSize":16,"totalPage":6,"pageCount":5,"totalSize":93}]}}