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DNLI’s wholly-owned program, tividenofusp alfa, is an Enzyme Transport Vehicle-enabled iduronate-2-sulfatase replacement therapy in development for MPS II.Per the additional long-term data readout from the phase I/II study, treatment with tividenofusp alfa resulted in significant and substantial reductions in key disease biomarkers within the central nervous system and peripheral system, bringing them to normal or near-normal levels. Such biomarkers included cerebrospinal fluid and urine heparan sulfate, as well as neurofilament light, a recognized marker of neurodegeneration.Per Denali, such efficacy data suggests the pervasive nature of treatment effects in MPS II patients over the longer term.Shares of DNLI have plunged 28.1% in the 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behaviorLong","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.globenewswire.com/news-release/2025/02/06/3022238/0/en/Denali-Therapeutics-Announces-Primary-Analysis-and-Long-Term-Follow-Up-of-Phase-1-2-Study-in-Hunter-Syndrome-MPS-II-with-Tividenofusp-Alfa.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["ETV","BK4139","LENZ","BK4548","DNLI","BK4100","TV","CSF","BK4535"],"gpt_icon":0},{"id":"2507407536","title":"Denali Therapeutics Announces Upcoming Presentations on Hunter Syndrome (Mps Ii) and Transportvehicle™ Enabled Investigational Therapeutic Tividenofusp Alfa at the 2025 Worldsymposium™","url":"https://stock-news.laohu8.com/highlight/detail?id=2507407536","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2507407536?lang=en_us&edition=fundamental","pubTime":"2025-01-30 21:00","pubTimestamp":1738242002,"startTime":"0","endTime":"0","summary":null,"market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250130:nTUA9YL9MR:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["BK4139","BK4535","BK4548","DNLI"],"gpt_icon":0},{"id":"2507407046","title":"Denali Therapeutics Announces Upcoming Presentations on Hunter Syndrome (MPS II) and TransportVehicle™ Enabled Investigational Therapeutic Tividenofusp Alfa at the 2025 WORLDSymposium™","url":"https://stock-news.laohu8.com/highlight/detail?id=2507407046","media":"GlobeNewswire","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2507407046?lang=en_us&edition=fundamental","pubTime":"2025-01-30 21:00","pubTimestamp":1738242000,"startTime":"0","endTime":"0","summary":"The presentation schedule at WORLDSymposium 2025 is as follows:. Title: Age-Dependent Reference Intervals for Cerebrospinal Fluid  and Urine Heparan Sulfate  and Dermatan Sulfate  and CSF Gangliosides – Poster #132Session: Clinical Applications – Poster Session IIIDate: Thursday, February 6, 2025Session Time: 3:30 – 5:30 PM Pacific Time. Denali is also sponsoring the following satellite symposium event at WORLDSymposium 2025:. Title: Voices in Unison – Insights into the Unmet Needs in MPS II from Patient Community and Physician Perspectives Date: Wednesday, February 5, 2025Time: 6:45 – 7:45 AM Pacific Time. Cautionary Note Regarding Forward-Looking StatementsThis press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements expressed or implied in this press release include, but are not limited to, statements by Denali Therapeutics Inc.  regarding Denali’s planned presentations and events at the ","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/denali-therapeutics-announces-upcoming-presentations-130000491.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["CSF","BK4535","DNLI","TV","LENZ","BK4139","BK4100","BK4548"],"gpt_icon":0},{"id":"2505247832","title":"Denali Gains 26.6% in a Year: How Should You Play the Stock?","url":"https://stock-news.laohu8.com/highlight/detail?id=2505247832","media":"Zacks","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2505247832?lang=en_us&edition=fundamental","pubTime":"2025-01-21 19:13","pubTimestamp":1737457980,"startTime":"0","endTime":"0","summary":"Denali Therapeutics DNLI has performed well in the past 12 months amid a volatile market. Shares of the company have gained 26.6% against the industry’s decline of 14.3%. The stock has also outperformed the sector and the S&P 500 Index in this time frame.Denali is developing a broad portfolio of product candidates engineered to cross the blood-brain barrier for the treatment of neurodegenerative and lysosomal storage diseases. The upward price trajectory can be attributed to positive pipeline updates.Denali recently announced expected milestones for 2025 and its priorities to further advance its portfolio.DNLI is evaluating DNL126 for Sanfilippo syndrome type A . Preliminary data from the ongoing phase I/II study of DNL126 have demonstrated a substantial reduction in cerebrospinal fluid heparan sulfate  levels from baseline, including normalization. Denali will seek alignment with the FDA on a path for accelerated approval based on these encouraging results. The candidate has been sele","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/denali-gains-26-6-play-111300399.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["LU0889565916.HKD","BK4139","LU0320765992.SGD","BK4533","IE00B19Z9P08.USD","BK4548","IE00BFXG1179.USD","BK4585","SNY","IE00B894F039.SGD","BK4535","IE00B19Z9Z06.USD","BIIB","DNLI","BK4007","BK4532","LU0234570918.USD","BK4588","LU0109394709.USD"],"gpt_icon":0},{"id":"2504957261","title":"Why Denali Therapeutics (DNLI) Is the Biotech Stock with Biggest Upside Potential","url":"https://stock-news.laohu8.com/highlight/detail?id=2504957261","media":"Insider Monkey","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2504957261?lang=en_us&edition=fundamental","pubTime":"2025-01-18 00:18","pubTimestamp":1737130682,"startTime":"0","endTime":"0","summary":"We recently published a list of the 12 Biotech Stocks with the Biggest Upside Potential. In this article, we are going to take a look at where Denali Therapeutics, Inc.  stands against other biotech stocks with the biggest upside potential.While 2024 was a “challenging” year for biotech stocks, JPMorgan is of the view that some names in the industry may be poised for considerable upside in the coming months. On November 28, Johan Hueffer, senior partner and principal of investments at Novo Holdings, appeared on CNBC to discuss his macro perspective on investments in life sciences. He said that biotechs faced difficulty raising capital in the last couple of years. However, that trend has started to improve in the last quarter or two.Flood’s note also highlighted that the biotech industry has recently shown improved fundamentals, attributed to a more favorable regulatory environment and positive clinical outcomes. Despite these tailwinds, Goldman’s data reflects that biotechnology remain","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/why-denali-therapeutics-dnli-biotech-161802993.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["QLD","BK4077","MNQmain","TQQQ","NVIW.SI",".IXIC","IE0004091025.USD","US2Y.BOND","LU2237443978.SGD","LU2237443382.USD","US10Y.BOND","BK4535","LU2237438978.USD","IE0034235188.USD","LU2237443622.USD","PSQ","IE00B19Z3B42.SGD","SQQQ","IE00BFXG1179.USD","USJW.SI","BK4516","BK4552","QID","DNLI","TV","FOMC","LU0106831901.USD","BK4127","BK4533","US12M.BOND","LU1668664300.SGD","LU2237443895.HKD","BK4550","US7Y.BOND","BK4588","NQmain","IE00BSNM7G36.USD","LU2237443465.HKD","US30Y.BOND","USAW.SI","IE0002270589.USD","BK4504","US3Y.BOND","US5Y.BOND","TSYW.SI","US6M.BOND","LU2237443549.SGD","LU1791807156.HKD","IE0004086264.USD"],"gpt_icon":1}],"pageSize":16,"totalPage":6,"pageCount":2,"totalSize":94}]}}