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The news “portends a material fundamental setback for the program, either for reasons of safety or futile activity,” the analyst tells investors in a research note. The firm says that with little pipeline value beyond bexotograst, it sees share downside to $3-$4 on the update, in line with the company’s year-end estimated cash. The stock in premarket trading is down 60%, or $4.780, to $3.09.Leverage the power of TipRanks' Smart Score, a data-driven tool to help you uncover top performing stocks and make informed investment decisions.Monitor your stock picks and compare them to top Wall Street Analysts' recommendations with  Your Smart Portfolio. Pliant Therapeutics downgraded to Perform from Outperform at Oppenheimer. 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The company is in advanced talks to be acquired by Merck KGaA, Reuters reported.Axsome Therapeutics  shares rose 21% after the firm said it agreed to a settlement deal with Teva  to resolve patent litigation over its Auvelity product. Teva was down 0.8%.Pliant Therapeutics  shares fell 59% after the firm paused enrollment and dosing in a phase 2b trial of bexotegrast in idiopathic pulmonary fibrosis patients. Several analysts  downgraded the stock following the announcement.","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["AXSM","BK4585","BK4596","BK4139","BK4505","IBB","PLRX","BK4557","TEVA","BK4559","BK4588","SWTX","BK4581","XLV","BK4566","BK4007","BK4584"],"gpt_icon":0},{"id":"2510895494","title":"Pliant Therapeutics Pauses Enrollment in BEACON-IPF Trial, Shares Take Steep Dive","url":"https://stock-news.laohu8.com/highlight/detail?id=2510895494","media":"GuruFocus.com","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2510895494?lang=en_us&edition=fundamental","pubTime":"2025-02-11 02:15","pubTimestamp":1739211344,"startTime":"0","endTime":"0","summary":"Pliant Therapeutics  shares tumbled 58.8% to $3.21 as of 12:40 p.m. ET on Monday, following a 34.8% decline on Friday, after the company announced a voluntary pause in enrollment and dosing for its BEACON-IPF Phase 2b trial.GuruFocus has detected 3 Warning Signs with PLRX.The independent Data Safety Monitoring Board of the trial is cited as the reason for the choice.1 integrins, proteins linked in fibrosis, Bexotegrast is an oral small-molecule inhibitor being studied. The U.S. Food and Drug Administration has assigned it Fast Track and Orphan Drug designations; the European Medicines Agency has assigned it Orphan Drug status. The BEACON-IPF study is assessing the medication as a possible therapy for the progressive lung illness known as idiopathic pulmonary fibrosis, for which there are few therapeutic choices.Pliant said it is still dedicated to working with authorities and the DSMB to decide the best course ahead, but it did not provide a restarting enrollment timetable. As addition","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/pliant-therapeutics-pauses-enrollment-beacon-181544794.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-2","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["BK4007","BK4139","PLRX","LENZ"],"gpt_icon":0},{"id":"2510186267","title":"Pliant Therapeutics Shares Tumble Amid Analyst Downgrades Following Study Suspension","url":"https://stock-news.laohu8.com/highlight/detail?id=2510186267","media":"MT Newswires Live","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2510186267?lang=en_us&edition=fundamental","pubTime":"2025-02-11 00:24","pubTimestamp":1739204680,"startTime":"0","endTime":"0","summary":"Pliant Therapeutics  shares fell 60% in recent Monday trading after several investment firms downgraded their ratings on the company following its announcement late Friday that it has suspended enrollment and dosing in a phase 2b trial of bexotegrast for idiopathic pulmonary fibrosis.RBC downgraded Pliant to sector perform from outperform and cut its price target to $4 from $45, Oppenheimer downgraded the company to perform from outperform, HC Wainwright downgraded it to neutral from buy, Citigroup downgraded it to neutral from buy, with a $4 price target, and Wells Fargo downgraded it to equalweight from overweight, with a $4 price target.Price: 3.09, Change: -4.70, Percent Change: -60.36","market":"sg","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-2","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["PLRX","LENZ"],"gpt_icon":0},{"id":"2510864483","title":"Pliant Therapeutics Cut to Hold From Buy by Canaccord Genuity","url":"https://stock-news.laohu8.com/highlight/detail?id=2510864483","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2510864483?lang=en_us&edition=fundamental","pubTime":"2025-02-10 23:50","pubTimestamp":1739202600,"startTime":"0","endTime":"0","summary":"Ratings actions from Benzinga: https://www.benzinga.com/quote/PLRX/analyst-ratings \n\n\n \n\n\n  (END) Dow Jones Newswires\n\n\n  February 10, 2025 10:50 ET (15:50 GMT)","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4007","BK4139","PLRX","LENZ"],"gpt_icon":0},{"id":"2510866598","title":"Pliant Therapeutics Shares Fall 60.2% After Co Halts Enrollment in Mid-Stage Trial for Lung Disease Treatment","url":"https://stock-news.laohu8.com/highlight/detail?id=2510866598","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2510866598?lang=en_us&edition=fundamental","pubTime":"2025-02-10 23:06","pubTimestamp":1739199968,"startTime":"0","endTime":"0","summary":null,"market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250210:nFWN3P1167:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["PLRX","BK4007"],"gpt_icon":0},{"id":"2510663268","title":"Pliant Therapeutics Cut to Equal-Weight From Overweight by Wells Fargo","url":"https://stock-news.laohu8.com/highlight/detail?id=2510663268","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2510663268?lang=en_us&edition=fundamental","pubTime":"2025-02-10 22:50","pubTimestamp":1739199000,"startTime":"0","endTime":"0","summary":"Ratings actions from Benzinga: https://www.benzinga.com/quote/PLRX/analyst-ratings \n\n\n \n\n\n  (END) Dow Jones Newswires\n\n\n  February 10, 2025 09:50 ET (14:50 GMT)","market":"other","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["PLRX","LENZ"],"gpt_icon":0},{"id":"2510868154","title":"Pliant Therapeutics Inc : Wells Fargo Cuts Target Price to $4 From $41","url":"https://stock-news.laohu8.com/highlight/detail?id=2510868154","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2510868154?lang=en_us&edition=fundamental","pubTime":"2025-02-10 22:26","pubTimestamp":1739197598,"startTime":"0","endTime":"0","summary":null,"market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250210:nFWN3P114H:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["PLRX","BK4007"],"gpt_icon":0},{"id":"2510868157","title":"Pliant Therapeutics Inc : Wells Fargo Cuts to Equal Weight From Overweight","url":"https://stock-news.laohu8.com/highlight/detail?id=2510868157","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2510868157?lang=en_us&edition=fundamental","pubTime":"2025-02-10 22:26","pubTimestamp":1739197587,"startTime":"0","endTime":"0","summary":null,"market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250210:nFWN3P111Q:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["PLRX","BK4007"],"gpt_icon":0},{"id":"2510850272","title":"Sector Update: Health Care Stocks Flat to Edging Higher Pre-Bell Monday","url":"https://stock-news.laohu8.com/highlight/detail?id=2510850272","media":"MT Newswires Live","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2510850272?lang=en_us&edition=fundamental","pubTime":"2025-02-10 22:10","pubTimestamp":1739196622,"startTime":"0","endTime":"0","summary":"Health care stocks were flat to edging higher pre-bell Monday as the iShares Biotechnology ETF  was inactive and the Health Care Select Sector SPDR Fund  was up 0.2% recently.Pliant Therapeutics  shares declined by nearly 61% after the company said it has suspended enrollment and treatment in a phase 2b trial of bexotegrast for idiopathic pulmonary fibrosis following a recommendation from the trial's data safety monitoring board.Roivant Sciences  shares were up nearly 6% even after the company reported lower fiscal Q3 earnings and revenue.DocGo  shares rose past 3% after the company said it has acquired PTI Health to add mobile phlebotomy lab services to its portfolio.","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["BK4007","IBB","DCGO","XLV","PLRX","BK4581","BK4139","BK4585","BK4196","BK4588","ROIV"],"gpt_icon":0},{"id":"2510485702","title":"Pliant Therapeutics Inc : JP Morgan Cuts to Neutral From Overweight","url":"https://stock-news.laohu8.com/highlight/detail?id=2510485702","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2510485702?lang=en_us&edition=fundamental","pubTime":"2025-02-10 21:57","pubTimestamp":1739195874,"startTime":"0","endTime":"0","summary":null,"market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20250210:nFWN3P111E:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["PLRX","BK4007"],"gpt_icon":0},{"id":"2510857623","title":"Pliant Therapeutics Pauses Lead Product Mid-Stage Trial In Patients With Stiff Lung Tissues","url":"https://stock-news.laohu8.com/highlight/detail?id=2510857623","media":"Benzinga","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2510857623?lang=en_us&edition=fundamental","pubTime":"2025-02-10 21:32","pubTimestamp":1739194324,"startTime":"0","endTime":"0","summary":"Pliant Therapeutics, Inc.  stock is trading lower on Monday.On Friday, during after-hours trading, Pliant Therapeutics announced it has voluntarily paused enrollment and dosing in the ongoing BEACON-IPF Phase 2b trial of bexotegrast in patients with idiopathic pulmonary fibrosis , a chronic lung disease that causes scarring and stiffening of the lung tissue.Patients currently enrolled in BEACON-IPF will remain in the trial.The move follows a prespecified data review and recommendations by the trial’s independent Data Safety Monitoring Board.In May 2024, On Tuesday,Pliant Therapeutics announced topline data from a Phase 2a PET Imaging trial ofbexotegrast evaluating change in total collagen levels in the lungs of patients with idiopathic pulmonary fibrosis  characterized by excessive collagendeposition in the lung.Last February, Pliant Therapeutics released 12-week interim data from the 320 mg dose group of INTEGRIS-PSC Phase 2a trial of bexotegrast in patients with primary sclerosing ch","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/pliant-therapeutics-pauses-lead-product-133204055.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["BK4139","BK4192","SSI","PET","PSC","BK4007","PLRX","LENZ"],"gpt_icon":0},{"id":"2510623854","title":"Pliant Therapeutics Inc. : Oppenheimer Cuts to Perform From Outperform","url":"https://stock-news.laohu8.com/highlight/detail?id=2510623854","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2510623854?lang=en_us&edition=fundamental","pubTime":"2025-02-10 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nearly 64% pre-bell Monday after the company said late Friday it has suspended enrollment and treatment in a phase 2b trial of bexotegrast for idiopathic pulmonary fibrosis.Semtech  stock was more than 27% lower, adding to Friday's losses.Bellevue Life Science Acquisition  shares were down 8% lower after a 1.6% loss in the previous session.","market":"sg","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.mtnewswires.com/","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"mtnewswires_news","symbols":["SMTC","BLAC","BK4588","BK4141","PLRX","BK4585","BK4007"],"gpt_icon":0}],"pageSize":16,"totalPage":5,"pageCount":3,"totalSize":80}]}}