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The company is gearing up to initiate a mid-stage study of the candidate for the essential tremor indication in 2026.This strategic move aligns with ACAD’s longstanding commitment to delivering innovative therapies for patients with central nervous system disorders. Per the company, essential tremor has lacked innovative treatment options for decades, highlighting a significant unmet need. Leveraging Acadia’s extensive expertise in developing and commercializing advanced therapies for neurological disorders, the company aims to address this gap through its work with SAN711.Year to date, shares of Acadia have plunged 48.2% compared with the industry’s 7.8% decline.Revenues generated from the sales of Nuplazid are the majority contributor to Acadia’s top line. In the nine months ended Sept. 30, 2024, Nuplazid s","market":"us","thumbnail":"https://s.yimg.com/uu/api/res/1.2/.UMP6LIbiG0Pb3tKR9RYYw--~B/aD00MDA7dz02MzU7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/1566882a22938942efee3e7508e93e96","type":0,"news_type":0,"thumbnails":["https://s.yimg.com/uu/api/res/1.2/.UMP6LIbiG0Pb3tKR9RYYw--~B/aD00MDA7dz02MzU7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/1566882a22938942efee3e7508e93e96"],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/acad-signs-license-deal-saniona-150600406.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"corporation","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["LU2065169927.USD","IE00BBT3K403.USD","IE00BYQQ9H92.USD","LU0225771236.USD","BK4130","LU0823417653.USD","IE00BZ1G4Q59.USD","BK4592","ALLO","IE00BFXG0V08.USD","LU2065171402.SGD","PFE","LU0306806265.USD","LU0545562505.USD","LU0456855351.SGD","LU1066053197.SGD","BK4007","LU1228905037.USD","LU2065171311.SGD","ADP","PWS","GILD","LU0170899867.USD","LU0122379950.USD","SG9999003800.SGD","LU0321505439.SGD","ACAD","LU0345774631.USD","BK4583","BK4578","BK4550","LU0889565916.HKD","BK4528","BK4505","LU0690374615.EUR","LU2506952170.USD","LU0058720904.USD","LU0109394709.USD","LU1585245621.USD","LU1221951129.SGD","LU0823417737.USD","LU1066051498.USD","LU0225284248.USD","BK4533","LU1691799644.USD","BK4566","LU1571399168.USD","IE000M9KFDE8.USD","LU0234570918.USD","LU1228905540.USD"],"gpt_icon":1},{"id":"2486649888","title":"FDA Begins Review of Alnylam's sNDA for Expanded Amvuttra Use","url":"https://stock-news.laohu8.com/highlight/detail?id=2486649888","media":"Zacks","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2486649888?lang=en_us&edition=fundamental","pubTime":"2024-11-26 22:28","pubTimestamp":1732631280,"startTime":"0","endTime":"0","summary":"The sNDA has been accepted for review under the FDA’s Priority Review pathway. A filing designated as a Priority Review reduces the review period to four months. A final decision from the regulatory body is expected on March 23, 2025. Furthermore, the FDA has informed Alnylam that it does not plan to hold an advisory committee meeting to review the application.Subject to approval, vutrisiranwill become the first therapeutic approved in theUnited Statesto treat both the polyneuropathy manifestations of hATTR and cardiomyopathy manifestations of ATTR amyloidosis.The application seeking approval for Amvuttra to treat ATTR-CM is supported by positiveresults from Alnylam’s pivotal phase III HELIOS-B study, which met all primary and secondary endpoints across both the overall and monotherapy populations, each with statistical significance.Year to date, shares of Alnylam have gained 31.1% against the industry’s 9% decline.","market":"us","thumbnail":"https://s.yimg.com/uu/api/res/1.2/TnZya4zmXcZQTiM85rn8xg--~B/aD00MDA7dz02MzU7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/955c0f2ed0992898cedf76a9efa5b1f2","type":0,"news_type":0,"thumbnails":["https://s.yimg.com/uu/api/res/1.2/TnZya4zmXcZQTiM85rn8xg--~B/aD00MDA7dz02MzU7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/955c0f2ed0992898cedf76a9efa5b1f2"],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/fda-begins-review-alnylams-snda-142800088.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["BK4578","ALNY","BBIO","IE0002141913.USD","BK4505","ALLO","IE00BJT1NW94.SGD","BK4585","IE00BFTCPJ56.SGD","BK4548","IE0009355771.USD","BK4007","NVS","BK4588","BK4532","IE00B4R5TH58.HKD","IE00B2B36J28.USD","IE00BJJMRZ35.SGD","LU0211331839.USD","BK4139"],"gpt_icon":0},{"id":"2486056396","title":"Allogene Therapeutics (ALLO) Upgraded to Buy: Here's Why","url":"https://stock-news.laohu8.com/highlight/detail?id=2486056396","media":"Zacks","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2486056396?lang=en_us&edition=fundamental","pubTime":"2024-11-26 01:00","pubTimestamp":1732554011,"startTime":"0","endTime":"0","summary":"Allogene Therapeutics  could be a solid choice for investors given its recent upgrade to a Zacks Rank #2 . This upgrade primarily reflects an upward trend in earnings estimates, which is one of the most powerful forces impacting stock prices.The Zacks rating relies solely on a company's changing earnings picture. It tracks EPS estimates for the current and following years from the sell-side analysts covering the stock through a consensus measure -- the Zacks Consensus Estimate.Since a changing earnings picture is a powerful factor influencing near-term stock price movements, the Zacks rating system is very useful for individual investors. They may find it difficult to make decisions based on rating upgrades by Wall Street analysts, as these are mostly driven by subjective factors that are hard to see and measure in real time.As such, the Zacks rating upgrade for Allogene Therapeutics is essentially a positive comment on its earnings outlook that could have a favorable impact on its sto","market":"us","thumbnail":"https://s.yimg.com/uu/api/res/1.2/UPInF06X6fJkTqeimnpZuQ--~B/aD03NDU7dz05MDA7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/078b2d95159d12a337f09f2519ff10ba","type":0,"news_type":0,"thumbnails":["https://s.yimg.com/uu/api/res/1.2/UPInF06X6fJkTqeimnpZuQ--~B/aD03NDU7dz05MDA7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/078b2d95159d12a337f09f2519ff10ba"],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/allogene-therapeutics-allo-upgraded-buy-170011541.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["ALLO"],"gpt_icon":0},{"id":"2485294516","title":"Replimune Stock Rallies on BLA Filing for Melanoma Combo Drug","url":"https://stock-news.laohu8.com/highlight/detail?id=2485294516","media":"Zacks","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2485294516?lang=en_us&edition=fundamental","pubTime":"2024-11-23 00:23","pubTimestamp":1732292580,"startTime":"0","endTime":"0","summary":"Replimune GroupREPL announced that it has submitted a biologics license application  to the FDA forits lead pipeline candidate, RP1, in combination withBristol Myers’BMY blockbuster immuno-oncology drug Opdivo  to treat adult patients with anti-PD1 failed advanced melanoma. The regulatory filing has been made under the FDA’s Accelerated Approval pathway. In response to the encouraging news, the stock rose 19.4% in the after-market hours on Thursday. The stock is also rising today during the pre-market hours.RP1 is based on a proprietary strain of herpes simplex virus, engineered and genetically armed with a fusogenic protein  and GM-CSF, intended to maximize tumor killing potency, the immunogenicity of tumor cell death and the activation of a systemic anti-tumor immune response.REPL’s RP1 BLA Submission Supported by Robust Study Data. Replimune’s BLA submission for RPI, in combination with Bristol Myers’ Opdivo, for the advanced melanoma indication is supported by positive top-line res","market":"us","thumbnail":"https://s.yimg.com/uu/api/res/1.2/OqpBwYnlazUrZRs4ONCSFw--~B/aD00MDA7dz02MzU7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/3ecb7b8f4826ee26a884371aa5efe958","type":0,"news_type":0,"thumbnails":["https://s.yimg.com/uu/api/res/1.2/OqpBwYnlazUrZRs4ONCSFw--~B/aD00MDA7dz02MzU7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/3ecb7b8f4826ee26a884371aa5efe958"],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/replimune-stock-rallies-bla-filing-162300397.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["IE00BJJMRZ35.SGD","LU1032466523.USD","LU0985481810.HKD","LU0170899867.USD","SG9999013999.USD","LU0306806265.USD","LU2360032135.SGD","LU1670711040.USD","LU1883839398.USD","HCC","BK4585","IE0002270589.USD","BK4559","LU1718418525.SGD","BMY","SG9999001176.SGD","BK4588","LU1430594728.SGD","LU1585245621.USD","IE0009355771.USD","SG9999002224.SGD","ALLO","LU1894683348.USD","IE00B19Z3581.USD","IE00BLSP4239.USD","LU0237698245.USD","LU2242646821.SGD","IE0002141913.USD","IE00BSNM7G36.USD","LU0234572021.USD","LU1057294990.SGD","LU1093756168.USD","LU1868836591.USD","IE00BFTCPJ56.SGD","IE00BLSP4452.SGD","LU1066053197.SGD","PFE","BK4581","LU0114720955.EUR","SG9999011175.SGD","BK4532","LU1261432733.SGD","BK4505","SGXZ57979304.SGD","BK4007","SG9999002232.USD","BK4139","LU0289739699.SGD","REPL","LU0868494617.USD"],"gpt_icon":1},{"id":"2485125830","title":"SLN Stock Down Despite Cholesterol Drug Lowering Lipoprotein Levels","url":"https://stock-news.laohu8.com/highlight/detail?id=2485125830","media":"Zacks","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2485125830?lang=en_us&edition=fundamental","pubTime":"2024-11-21 00:04","pubTimestamp":1732118640,"startTime":"0","endTime":"0","summary":"The results from the phase II ALPACAR-360 study of zerlasiran for the ASCVD indication were presented at a medical conference in Chicago, IL, and simultaneously published in the Journal of the American Medical Association.Per the data readout, zerlasiran, administered at doses of 300 mg every 16 or 24 weeks or 450 mg every 24 weeks, achieved more than 80% mean time-averaged placebo-adjusted reductions in Lp levels over 36 weeks, with maximum reductions surpassing 90%. At the final follow-up, 60 weeks after the initial dose, Lp reductions were sustained, and the treatment remained safe with infrequent dosing.However, it was also observed that Lp reduction levels with zerlasiran in the ALPACAR-360 study declined between the 16 weeks and 24 weeks 300mg doses, signifying diminishing efficacy. This has raised questions regarding the competitive profile of the drug compared to a therapeutic candidate being developed by Amgen AMGN for the same indication.Year to date, shares of Silence Therap","market":"us","thumbnail":"https://s.yimg.com/uu/api/res/1.2/QsgmBPisi3OOmQsNZTidNg--~B/aD0zNDk7dz02MjA7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/048cb98376b33bd6dcff462577373727","type":0,"news_type":0,"thumbnails":["https://s.yimg.com/uu/api/res/1.2/QsgmBPisi3OOmQsNZTidNg--~B/aD0zNDk7dz02MjA7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/048cb98376b33bd6dcff462577373727"],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/sln-stock-down-despite-cholesterol-160400416.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["IE00BJT1NW94.SGD","LU0321505868.SGD","LU2112291526.USD","BK4581","LU0225284248.USD","IE00BJJMRZ35.SGD","IE00B4R5TH58.HKD","LU1057294990.SGD","BK4568","LU2242652126.USD","AMGN","BK4505","LU1066053197.SGD","IE00BBT3K403.USD","LU0306807586.USD","LU0889565916.HKD","SG9999002232.USD","SG9999011175.SGD","IE00B19Z3B42.SGD","ALLO","IE00B19Z3581.USD","BK4599","IE00BLSP4452.SGD","BK4533","BK4550","LU1894683264.USD","IE0002270589.USD","LU0985481810.HKD","BK4588","BK4592","LU1061106388.HKD","IE000M9KFDE8.USD","LU0225771236.USD","BK4007","IE00B2B36J28.USD","PFE","LU1066051498.USD","LU0289739699.SGD","SLN","IE0002141913.USD","LU0321505439.SGD","SG9999001440.SGD","IE0009355771.USD","SG9999013999.USD","SG9999001176.USD","LU0456855351.SGD","LU0122379950.USD","LU0868494617.USD","BK4585","BK4566"],"gpt_icon":1},{"id":"2484278921","title":"ACRS Stock Up on Licensing Deal With Biosion for Two Immunology Drugs","url":"https://stock-news.laohu8.com/highlight/detail?id=2484278921","media":"Zacks","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2484278921?lang=en_us&edition=fundamental","pubTime":"2024-11-19 22:19","pubTimestamp":1732025940,"startTime":"0","endTime":"0","summary":"Shares of Aclaris Therapeutics ACRS rallied 53.2% on Monday and gained another 8.9% during the after-market hours following the signing of an exclusive license agreement withBiosion for global rights to two of the latter’s pipeline candidates, BSI-045B and BSI-502.Biosion’s BSI-045B, a novel anti-TSLP monoclonal antibody, is currently in clinical development in the United States for treating moderate-to-severe atopic dermatitis. Results from a completed phase IIa proof-of-concept study by Biosion demonstrated that BSI-045B has a pharmacodynamic, safety and efficacy profile indicative of its potential as a best-in-class therapy.Several mid-stage studies of the candidate are ongoing in China for severe asthma and chronic rhinosinusitis with nasal polyps, aiming to accelerate potential proof-of-concept demonstrations for additional indications. The other investigational candidate, per the terms of the licensing deal, is BSI-502, a potential best-in-class, novel bispecific antibody that is","market":"us","thumbnail":"https://s.yimg.com/uu/api/res/1.2/KEj1lCkxRqndrrMrF3m.HA--~B/aD00MDA7dz02MzU7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/9c7450ec9df154559fbeb393640d6629","type":0,"news_type":0,"thumbnails":["https://s.yimg.com/uu/api/res/1.2/KEj1lCkxRqndrrMrF3m.HA--~B/aD00MDA7dz02MzU7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/9c7450ec9df154559fbeb393640d6629"],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/acrs-stock-licensing-deal-biosion-141900379.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["LU0889565916.HKD","BK4550","LU0456855351.SGD","BK4578","BK4007","BK4533","LU0985481810.HKD","LU1894683348.USD","LU0109394709.USD","SG9999011175.SGD","IE00BLSP4452.SGD","IE00BSNM7G36.USD","LU0320765992.SGD","IE0002270589.USD","GILD","LU0321505439.SGD","LU1883839398.USD","SG9999003800.SGD","LU0289739699.SGD","ACRS","BK4505","IE00BZ1G4Q59.USD","LU1066051498.USD","LU0058720904.USD","BK4566","BK4581","LU1066053197.SGD","IE00BKVL7J92.USD","IE00B19Z3581.USD","IE00BBT3K403.USD","LU0234572021.USD","LU0306806265.USD","LU0225284248.USD","LU0868494617.USD","LU1430594728.SGD","LU0122379950.USD","SG9999013999.USD","BK4583","LU0234570918.USD","LU1585245621.USD","ALLO","BK4568","BK4585","BK4588","LU1839511570.USD","LU2468319806.SGD","LU2087621335.USD","LU1894683264.USD","SGXZ57979304.SGD","PFE"],"gpt_icon":1},{"id":"2484260388","title":"Eyenovia Stock Tumbles on Termination of Phase III Myopia Study","url":"https://stock-news.laohu8.com/highlight/detail?id=2484260388","media":"Zacks","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2484260388?lang=en_us&edition=fundamental","pubTime":"2024-11-18 22:49","pubTimestamp":1731941340,"startTime":"0","endTime":"0","summary":"Eyenovia, Inc.EYEN announced the decision to terminate a phase III study evaluating its investigational drug-device product, MicroPine, as a potential treatment for pediatric progressive myopia. MicroPine is EYEN’s proprietary drug-device combination of low-dose atropine administered using the company’s Optejet dispensing platform.The decision was taken after an independent Data Review Committee  determined that the phase III CHAPERONEstudy of MicroPine was unlikely to meet its primary endpoint of less than 0.5 diopter progression in visual acuity over three years.The DRC evaluated safety and efficacy data from 252 patients and found no significant difference in myopia progression between the two treatment groups  and placebo. However, all doses of the candidate and the placebo were well-tolerated in the CHAPERONEstudy, with only mild and infrequent adverse events. The complete study data is yet to be provided to Eyenovia.Based on this DRC feedback, Eyenovia has decided to terminate th","market":"us","thumbnail":"https://s.yimg.com/uu/api/res/1.2/X5f0KWUqd43xLwLZQjf2Jw--~B/aD0zOTI7dz02MjA7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/83114bcf5a91754ed7ae3f6080390cd9","type":0,"news_type":0,"thumbnails":["https://s.yimg.com/uu/api/res/1.2/X5f0KWUqd43xLwLZQjf2Jw--~B/aD0zOTI7dz02MjA7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/83114bcf5a91754ed7ae3f6080390cd9"],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/eyenovia-stock-tumbles-termination-phase-144900203.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-2","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["LU0234572021.USD","LU0320765992.SGD","IE00B19Z3B42.SGD","IE0002270589.USD","EYEN","IE00BKVL7J92.USD","BK4578","BK4533","BK4583","LU1571399168.USD","LU1894683348.USD","GILD","LU1057294990.SGD","ALLO","IE00BSNM7G36.USD","IE00BLSP4452.SGD","LU2087621335.USD","IE00BBT3K403.USD","LU1023059063.AUD","SG9999013999.USD","LU2468319806.SGD","LU0321505439.SGD","LU1894683264.USD","SGXZ57979304.SGD","SG9999001176.SGD","LU0234570918.USD","BK4505","SG9999002232.USD","BK4566","BK4592","LU0225771236.USD","BK4139","BK4568","IE00B19Z3581.USD","LU0289739699.SGD","LU0868494617.USD","III","LU0985481810.HKD","BK4007","BK4581","PFE","LU0306807586.USD","LU1066051498.USD","BK4532","BK4134","LU0058720904.USD","SG9999002224.SGD","LU1066053197.SGD","BK4585","BK4550"],"gpt_icon":1},{"id":"2484234674","title":"ALNY Reports Sustained 6-Month Efficacy Data From Amyloidosis Study","url":"https://stock-news.laohu8.com/highlight/detail?id=2484234674","media":"Zacks","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2484234674?lang=en_us&edition=fundamental","pubTime":"2024-11-18 22:26","pubTimestamp":1731939960,"startTime":"0","endTime":"0","summary":"The ongoing phase I study evaluates the safety, tolerability, pharmacokinetic  and pharmacodynamic effects of nucresiran in 48 healthy adult subjects, who have been randomized in a ratio of 3:1 to receive either a single ascending dose of nucresiran or placebo. The study's primary endpoint is safety and secondary endpoints include the change from baseline in serum TTR over time, as well as characterization of plasma and urine PK of nucresiran.ALNY’s Amyloidosis Drug Shows Sustained 6-Month Efficacy. Per the data from an interim analysis of the phase I ATTR amyloidosis study, it was observed that a single 300 mg or higher dose of nucresiran quickly reduced serum TTR levels with low inter-patient variability, by more than 90% within 15 days, sustained through at least six months. At these dosage strengths, the reduction of mean TTR levels peaked at more than 96% by Day 29. Furthermore, serum TTR levelsremained significantly reduced, with a mean decrease of more than 70% at the one-year m","market":"us","thumbnail":"https://s.yimg.com/uu/api/res/1.2/kHYuj_GDhroF7BEQsCcsVA--~B/aD00MTM7dz02MjA7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/4658663242c3a61dee3fef55a1bf4887","type":0,"news_type":0,"thumbnails":["https://s.yimg.com/uu/api/res/1.2/kHYuj_GDhroF7BEQsCcsVA--~B/aD00MTM7dz02MjA7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/4658663242c3a61dee3fef55a1bf4887"],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/alny-reports-sustained-6-month-142600613.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["LU1066051498.USD","SG9999013999.USD","GILD","IE00BKVL7J92.USD","SG9999011175.SGD","BK4533","LU1839511570.USD","LU0985481810.HKD","LU1066053197.SGD","BK4532","SG9999001176.USD","IE00BZ1G4Q59.USD","LU0058720904.USD","IE00BLSP4452.SGD","LU0225771236.USD","LU0456855351.SGD","IE00BSNM7G36.USD","BK4534","BK4007","LU1057294990.SGD","SG9999002232.USD","SG9999003800.SGD","PFE","SG9999002224.SGD","IE00BBT3K403.USD","SG9999001176.SGD","BK4592","LU0321505439.SGD","PK","BK4568","BK4583","LU0889565916.HKD","LU0321505868.SGD","LU0320765992.SGD","BK4578","LU0306807586.USD","LU1894683264.USD","LU0234572021.USD","ALLO","IE000M9KFDE8.USD","ALNY","BK4139","LU1023059063.AUD","LU1585245621.USD","BK4566","LU1430594728.SGD","SGXZ57979304.SGD","BK4218","LU0868494617.USD","IE00B19Z3581.USD"],"gpt_icon":1},{"id":"2484678208","title":"Allogene Therapeutics presents data for ALLO-329 in autoimmune disease","url":"https://stock-news.laohu8.com/highlight/detail?id=2484678208","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2484678208?lang=en_us&edition=fundamental","pubTime":"2024-11-18 21:45","pubTimestamp":1731937526,"startTime":"0","endTime":"0","summary":"Allogene Therapeutics (ALLO) announced preclinical data for ALLO-329, an investigational allogeneic CD19/CD70 dual CAR T cell therapy being evaluat...","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/allogene-therapeutics-presents-data-for-allo-329-in-autoimmune-disease?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/allogene-therapeutics-presents-data-for-allo-329-in-autoimmune-disease?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["BK4505","BK4139","ALLO","CAR","BK4230","BK4022"],"gpt_icon":0},{"id":"2484562620","title":"Allogene Therapeutics Presents Preclinical Data for ALLO-329, an Allogeneic CD19/CD70 Dual CAR T for the Treatment of Autoimmune Disease at the American College of Rheumatology (ACR) Convergence","url":"https://stock-news.laohu8.com/highlight/detail?id=2484562620","media":"GlobeNewswire","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2484562620?lang=en_us&edition=fundamental","pubTime":"2024-11-18 21:30","pubTimestamp":1731936600,"startTime":"0","endTime":"0","summary":"ALLO-329 Induces Deep, Transient Depletion of CD19+ B Cells and CD70+ T Cells, and Reduction in IgG and IgM without Lymphodepletion in Humanized Murine ModelsProprietary Dagger Technology Enables ALLO","market":"hk","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.globenewswire.com/news-release/2024/11/18/2982777/0/en/Allogene-Therapeutics-Presents-Preclinical-Data-for-ALLO-329-an-Allogeneic-CD19-CD70-Dual-CAR-T-for-the-Treatment-of-Autoimmune-Disease-at-the-American-College-of-Rheumatology-ACR-.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["AFG","MLR","BK4107","BK4117","TRAC","BK4112","BK4139","BK4149","BK4022","BK4505","SLE","BK4230","BK4077","CAR","BK4110","ALLO","ACR"],"gpt_icon":0},{"id":"2483382416","title":"Syros Stock Plunges as Lead Cancer Study Fails to Meet Primary Goal","url":"https://stock-news.laohu8.com/highlight/detail?id=2483382416","media":"Zacks","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2483382416?lang=en_us&edition=fundamental","pubTime":"2024-11-14 23:24","pubTimestamp":1731597840,"startTime":"0","endTime":"0","summary":"However, Syros reported that the combo drug was well-tolerated by the total enrolled HR-MDS patient population in the SELECT-MDS-1 study. Moreover, the treatment-related adverse events were similar to those observed in earlier company-sponsored studies.Year to date, shares of SYRS have plunged 95.4% compared with theindustry’s 3.8% decline.Based on the disappointing outcome, Syros has decided to stop the HR-MDS study followed by a thorough review of the clinical data to evaluate the next steps. This is a huge setback for the company, leaving SYRS without a pipeline candidate. In the same press release, the company also stated that the failure of the SELECT-MDS-1 study to meet its primary endpoint constitutes an event of default under its secured loan facility with Oxford Finance.SYRS’ Termination of Mid-Stage Leukemia Study in August. The latest stock price drop marks the second pipeline setback for Syros in around three months. In August 2024, Syros stock plummeted after it discontinu","market":"us","thumbnail":"https://s.yimg.com/uu/api/res/1.2/T8SwUImUDIjgxL38j1nI4w--~B/aD00MTQ7dz02MjA7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/17664ed95646b97db9beb170298a16b3","type":0,"news_type":0,"thumbnails":["https://s.yimg.com/uu/api/res/1.2/T8SwUImUDIjgxL38j1nI4w--~B/aD00MTQ7dz02MjA7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/17664ed95646b97db9beb170298a16b3"],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/syros-stock-plunges-lead-cancer-152400773.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-2","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["CR","LU1003077747.HKD","SYRS","SG9999003800.SGD","SG9999015952.SGD","IE00B19Z9P08.USD","IE00B894F039.SGD","BK4139","LU2347655156.SGD","LU2087621335.USD","LU2237443382.USD","LU1989772840.SGD","LU0708994859.HKD","SG9999011175.SGD","BK4161","LU2237443978.SGD","IE00B19Z9Z06.USD","IE00BFTCPJ56.SGD","LU0211327993.USD","LU1496350171.SGD","LU0545039389.USD","BK4566","BK4588","LU0965509283.SGD","LU1244550494.USD","LU2023251221.USD","LU0203345920.USD","LU1093756325.SGD","ALLO","LU2237443895.HKD","LU1267930573.SGD","LU0882574055.USD","LU1430594728.SGD","BK4505","LU0203347892.USD","ABBV","LU1551013342.USD","LU2133065610.SGD","LU0689472784.USD","LU1983299246.USD","LU1718418525.SGD","LU0820561818.USD","LU2089284900.SGD","LU0211328371.USD","LU1244550577.SGD","LU0820561909.HKD","BIIB","LU0889565916.HKD","LU1934455863.HKD","LU0738911758.USD"],"gpt_icon":0},{"id":"2483371358","title":"Xenon Q3 Loss Narrower Than Expected, Pipeline Development in Focus","url":"https://stock-news.laohu8.com/highlight/detail?id=2483371358","media":"Zacks","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2483371358?lang=en_us&edition=fundamental","pubTime":"2024-11-13 23:50","pubTimestamp":1731513000,"startTime":"0","endTime":"0","summary":"Xenon Pharmaceuticals Inc.XENE reported a loss of 81 cents per share for the third quarter of 2024, narrower than the Zacks Consensus Estimate of a loss of 82 cents. The company had incurred a loss of 73 cents per share in the year-ago quarter.In the reported quarter, Xenon did not generate any revenues. Due to the absence of a marketed product, the company only recognizes periodic collaboration revenues in its top line from its ongoing partnership with Neurocrine Biosciences NBIX for XEN901, now known as NBI-921352. The company did not recognize any revenues in the year-ago quarter as well.NBI-921352 is a selective Nav1.6 sodium channel inhibitor. Neurocrine is currently evaluating NBI-921352 in a phase II study to treat patients aged 2-21 years with SCN8A developmental and epileptic encephalopathy. Per the terms of the agreement with NBIX, Xenon is eligible to receive certain clinical, regulatory and commercial milestone-based payments, as well as royalties on future sales.Xenon, in ","market":"us","thumbnail":"https://s.yimg.com/uu/api/res/1.2/kHYuj_GDhroF7BEQsCcsVA--~B/aD00MTM7dz02MjA7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/4658663242c3a61dee3fef55a1bf4887","type":0,"news_type":0,"thumbnails":["https://s.yimg.com/uu/api/res/1.2/kHYuj_GDhroF7BEQsCcsVA--~B/aD00MTM7dz02MjA7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/4658663242c3a61dee3fef55a1bf4887"],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/xenon-q3-loss-narrower-expected-155000607.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["IE00B894F039.SGD","BK4585","LU2065170008.USD","LU2065171311.SGD","IE00B19Z9Z06.USD","BK4533","LU2065171402.SGD","BK4532","LU2324357040.USD","NBIX","IE00B19Z9P08.USD","LU0234570918.USD","LU0109394709.USD","BK4505","LU0889565916.HKD","LU0320765992.SGD","LU2065169927.USD","BIIB","ALLO","XENE","BK4139","LU0823416689.USD","BK4588","ABVC"],"gpt_icon":0},{"id":"2483111038","title":"AbbVie Stock Declines as Schizophrenia Studies Fail, BMY Gains","url":"https://stock-news.laohu8.com/highlight/detail?id=2483111038","media":"Zacks","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2483111038?lang=en_us&edition=fundamental","pubTime":"2024-11-12 22:30","pubTimestamp":1731421800,"startTime":"0","endTime":"0","summary":"The studies were designed to show a statistically significant reduction  in the change from baseline in the Positive and Negative Syndrome Scale  total score upon treatment with the candidate compared with the placebo group at week 6. Please note that PANSS isa metric that measures the symptom severity of schizophrenia.The two phase II EMPOWERstudies evaluated emraclidineas a once-daily, oral monotherapy treatment for adults with schizophrenia who are experiencing an acute exacerbation of psychotic symptoms. Emraclidineis a potential novel M4-selective PAMin development for schizophrenia and Alzheimer's disease psychosis as a once-daily medication without the need for titration. Year to date, shares of AbbVie have gained 12.6% compared with the industry’s 11.5% growth.ABBV’s Schizophrenia Study Failures Boost BMY Stock. The failure of the EMPOWERstudies is a huge benefit for Bristol Myers as it reduces emerging competition for Cobenfy, which could have resulted in the stock price rise ","market":"us","thumbnail":"https://s.yimg.com/uu/api/res/1.2/D3ML88PGy1H5kHT9yl7OAw--~B/aD00MDA7dz02MzU7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/6c915f5bdd1c7ea850acb1ca1c067326","type":0,"news_type":0,"thumbnails":["https://s.yimg.com/uu/api/res/1.2/D3ML88PGy1H5kHT9yl7OAw--~B/aD00MDA7dz02MzU7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/6c915f5bdd1c7ea850acb1ca1c067326"],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/abbvie-stock-declines-schizophrenia-studies-143000633.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["LU0661504455.SGD","IE00B19Z9Z06.USD","LU1670710661.SGD","LU0882574055.USD","LU0912757837.SGD","LU0203345920.USD","LU0965508806.USD","IE00BGHQF631.EUR","LU0320765992.SGD","BIIB","LU1430594728.SGD","IE0009355771.USD","IE00B2B36J28.USD","LU2360032135.SGD","ALLO","LU1093756325.SGD","LU2242646821.SGD","LU0203347892.USD","BMY","LU1093756168.USD","IE00B3PB1722.GBP","LU1670710588.SGD","IE00B4R5TH58.HKD","LU0985481810.HKD","LU0949170772.SGD","BK4581","LU0029864427.USD","BK4533","BK4550","IE00B19Z9P08.USD","IE00BFTCPJ56.SGD","IE00BSNM7G36.USD","ABBV","LU0256863811.USD","LU1585245621.USD","IE00BJJMRZ35.SGD","LU0321505439.SGD","LU0170899867.USD","LU0310799852.SGD","IE00BJT1NW94.SGD","LU0321505868.SGD","LU0689472784.USD","LU0114720955.EUR","LU1074936037.SGD","LU2242652126.USD","LU0061475181.USD","LU0310800379.SGD","LU0985320562.USD","LU0795875086.SGD","LU1032466523.USD"],"gpt_icon":0},{"id":"2482322504","title":"JMP Securities Remains a Hold on Allogene Therapeutics (ALLO)","url":"https://stock-news.laohu8.com/highlight/detail?id=2482322504","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2482322504?lang=en_us&edition=fundamental","pubTime":"2024-11-11 13:26","pubTimestamp":1731302798,"startTime":"0","endTime":"0","summary":"In a report released today, Reni Benjamin from JMP Securities maintained a Hold rating on Allogene Therapeutics (ALLO – Research Report). The compa...","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/blurbs/jmp-securities-remains-a-hold-on-allogene-therapeutics-allo?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/blurbs/jmp-securities-remains-a-hold-on-allogene-therapeutics-allo?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["JMP","BK4505","ALLO","BK4139","BK4127"],"gpt_icon":0},{"id":"2482439537","title":"Nektar Q3 Loss Narrower Than Expected, Pipeline Development in Focus","url":"https://stock-news.laohu8.com/highlight/detail?id=2482439537","media":"Zacks","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2482439537?lang=en_us&edition=fundamental","pubTime":"2024-11-09 01:02","pubTimestamp":1731085320,"startTime":"0","endTime":"0","summary":"Nektar TherapeuticsNKTR incurred a loss per share of 18 cents in the third quarter of 2024, narrower than the Zacks Consensus Estimate of a loss of 23 cents.In the year-ago quarter, the company reported an adjusted  loss of 18 cents.Total revenues remained flat year over year at $24.1 million. The reported figure beat the Zacks Consensus Estimate of $16 million.See the ZacksEarnings Calendar to stay ahead of market-making news.Non-cash royalty revenues were $15.7 million, down around 13% from the year-ago quarter. However, the reported figure beat the Zacks Consensus Estimate of $13.9 million as well as our model estimate of $10.3 million.In November, Nektar signed a definitive agreement with Ampersand Capital Partners to sell its commercial PEGylation Reagent manufacturing business in Huntsville, AL, for $90 million. The sale includes $70 million in cash and $20 million in equity in the new portfolio company. The Huntsville facility will operate independently as an Ampersand portfolio","market":"us","thumbnail":"https://s.yimg.com/uu/api/res/1.2/vtsVt8PEmb10KQ4cnwEJfQ--~B/aD00MDA7dz02MzU7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/96776645e0ac7ab203b7d5e3b37251a6","type":0,"news_type":0,"thumbnails":["https://s.yimg.com/uu/api/res/1.2/vtsVt8PEmb10KQ4cnwEJfQ--~B/aD00MDA7dz02MzU7YXBwaWQ9eXRhY2h5b24-/https://media.zenfs.com/en/zacks.com/96776645e0ac7ab203b7d5e3b37251a6"],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://finance.yahoo.com/news/nektar-q3-loss-narrower-expected-170200070.html","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"yahoofinance","symbols":["LU0943347566.SGD","LU0471298777.SGD","LU0689472784.USD","LU0320765059.SGD","LU1064131342.USD","NKTR","BK4007","LU0882574055.USD","LU0471298694.HKD","LU0708995401.HKD","LU0211331839.USD","BK4505","BK4578","IE00B1BXHZ80.USD","LLY","LU0006306889.USD","IE0009355771.USD","LU0198837287.USD","LU0820561818.USD","NVS","LU0096364046.USD","ALLO","LU1061106388.HKD","LU0640476718.USD","GB00BDT5M118.USD","LU0354030511.USD","LU0820561909.HKD","LU0238689110.USD","LU0882574139.USD","IE00BK4W5M84.HKD","LU1023059063.AUD","LU0466842654.USD","LU0289739699.SGD","IE00BJLML261.HKD","LU1035775433.USD","LU1057294990.SGD","IE0002141913.USD","BK4581","IE00BFTCPJ56.SGD","LU0106261372.USD","LU0256863811.USD","LU1093756168.USD","BK4585","LU0203201768.USD","LU0672654240.SGD","LU0823416689.USD","IE0004445239.USD","LU0354030438.USD","LU0097036916.USD","LU0109391861.USD"],"gpt_icon":1},{"id":"1191888401","title":"Stock Track | Allogene Therapeutics Stock Plunges After Disappointing Earnings Report","url":"https://stock-news.laohu8.com/highlight/detail?id=1191888401","media":"Stock Track","labels":["movement"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/1191888401?lang=en_us&edition=fundamental","pubTime":"2024-11-09 00:48","pubTimestamp":1731084513,"startTime":"0","endTime":"0","summary":"Allogene Therapeutics Inc.  saw its stock price plummet by 6.58% on November 8, 2024, following the release of its earnings report for the quarter ended January 1, 2024.The biotechnology company reported a wider-than-expected adjusted loss of $0.32 per share for the quarter, missing analysts' expectations of a $0.33 loss per share. The company also failed to generate any revenue, while analysts had forecast revenue of $12,930.Allogene Therapeutics reported a quarterly loss of $66.29 million, ref","market":"us","thumbnail":"","type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":"","theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"movement","news_rank":0,"length":0,"strategy_id":0,"source":"ai_movement_en","symbols":["ALLO"],"gpt_icon":0}],"pageSize":16,"totalPage":5,"pageCount":3,"totalSize":80}]}}